Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization
نویسندگان
چکیده
منابع مشابه
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
With at least 1000 family members encoded by mammalian genomes, the G protein-coupled receptors (GPCRs) represent the most diverse group of signaling proteins known (Bockaert and Pin, 1999). GPCRs are involved in the regulation of a wide variety of physiological processes including, but not limited to, the sensory perceptions of pain, light, odors and tastes, cognition, muscle contraction, endo...
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A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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G protein-coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein-coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization. This review focuses on the regulation of GRK activity...
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The importance of G protein-coupled receptor (GPCR) kinases (GRKs) as regulators of GPCR signaling has been widely recognized. In humans, GRKs constitute a family of seven protein kinases involved in the phosphorylation and desensitization of agonist-activated GPCRs in many physiological processes. The GPCR desensitization process is initiated by GRKs, but involves several subsequent steps incl...
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For decades we have understood that G-protein-coupled receptors (GPCRs) are crucial links in the relay of information from extracellular stimuli to intracellular responses. Their importance is highlighted by the wide variety of GPCRs encoded in the human genome (Fredriksson et al., 2003; Perez, 2003) and the multiple mechanisms by which they are regulated (Clark, 1986; Palczewski and Benovic, 1...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2003
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.63.1.9